- 规格参数
- 产品介绍
- 售后保障
- 商品评价
- 仓储包装
- 常见问题
碧云天 Recombinant Huma... 当商品进行补货时,我们将以短信、邮件的形式通知您,最多发送一次,不会对您造成干扰。 |
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产品编号 | 产品名称 | 产品包装 | 产品价格 |
P5264-10μg | Recombinant Human IL-36γ, 169a.a. | 10μg | 1671.00元 |
P5264-100μg | Recombinant Human IL-36γ, 169a.a. | 100μg | 10650.00元 |
P5264-1mg | Recombinant Human IL-36γ, 169a.a. | 1mg | 34065.00元 |
Species | Gene ID | Accession | Source | Length | MW | Tag |
Human | 56300 | Q9NZH8 | E. coli | 169aa | 18.7kDa | - |
About this protein | |
Name | Recombinant Human IL-36γ, 169a.a. (Recombinant Human Interleukin-36γ, 169a.a.; rHuIL-36γ, 169a.a.);重组人白细胞介素36γ,169a.a. |
Synonyms | IL36G; IL1E; IL1F9; IL1H1; IL1RP2; UNQ2456/PRO5737 |
Purity | >95% by SDS-PAGE and HPLC analyses. |
Biological Activity | Fully biologically active when compared to standard. The specific activity is determined by its binding ability in a functional ELISA. Immobilized rHuIL-36γ at 1μg/ml can bind recombinant human IL-1 Rrp2 Fc Chimera with a range of 0.15-5μg/ml. |
Physical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. |
Formulation | Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH7.4. |
Endotoxin | Less than 1EU/μg of rHuIL-36γ, 169a.a. as determined by LAL method. |
Reconstitution | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in appropriate buffered solutions. |
Category | Cytokine |
Background | Interleukin-36 (IL-36) is a pro-inflammatory cytokine which plays an important role in the pathophysiology of several diseases. IL-36α, IL-36β, and IL-36γ (formerly IL-1F6, IL-1F8, and IL-1F9) are IL-1 family members that signal through the IL-1 receptor family members IL-1Rrp2 (IL-1RL2) and IL-1RAcP. IL-36γ is secreted when transfected into 293-T cells and it could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1). Furthermore, IL-36γ also can function as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2. Recombinant human IL-36γ is synthesized as a 19kDa, 169 amino acid (a.a.) protein that contains no signal sequence, no prosegment and no potential N-linked glycosylation site. Human to mouse, IL-36γ shares 53%a.a. identity. Within the family, IL-36γ shares about 25%~55%a.a. sequence identity with IL-1RA, IL-1β, IL-36RA, IL-36α, IL-37, IL-36β and IL-1F10. |
Amino Acid Sequence | MRGTPGDADG GGRAVYQSMC KPITGTINDL NQQVWTLQGQ NLVAVPRSDS VTPVTVAVIT CKYPEALEQG RGDPIYLGIQ NPEMCLYCEK VGEQPTLQLK EQKIMDLYGQ PEPVKPFLFY RAKTGRTSTL ESVAFPDWFI ASSKRDQPII LTSELGKSYN TAFELNIND |
包装清单:
产品编号 | 产品名称 | 包装 |
P5264-2μg | Recombinant Human IL-36γ, 169a.a. | 2μg |
P5264-10μg | Recombinant Human IL-36γ, 169a.a. | 10μg |
P5264-100μg | Recombinant Human IL-36γ, 169a.a. | 100μg |
P5264-1mg | Recombinant Human IL-36γ, 169a.a. | 1mg |
- | 说明书 | 1份 |
保存条件:
-20℃或更低温度保存,至少一年有效。由于蛋白的每次冻融均会引起部分失活,所以首次配制成相应浓度的储存液后(请根据产品简介中Reconstitution一栏的信息配制储存液),须分装后-20℃或更低温度冻存,以避免反复冻融。
注意事项:
由于有些塑料管壁对某些蛋白有较强的吸附作用,溶液中的蛋白很容易粘附在管壁上,并且粘附后的蛋白很难与管壁分离。而载体蛋白(Carrier protein,如0.1% BSA等)的主要作用是预先封闭塑料管壁上的蛋白结合位点,使细胞因子或重组蛋白不会粘附于管壁。所以一定要使用产品简介中Reconstitution一栏的信息配制储存液。
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